α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation

α-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and the administration of α-Mangostin inhibited the growth of transplanted colon cancer, Her/CT26 cells which expressed Her-2/neu as tumor antigen. Although α-Mangostin was reported to have inhibitory activity against sarco/endoplasmic reticulum Ca(2+) ATPase like thapsigargin, it showed diff...

متن کامل

α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation

Background Blocking of DNA synthesis through inhibition of ribonucleotide reductase has been proposed to be the main mechanism of anti-neoplastic action for a-N-heterocyclic thiosemicarbazones. Currently the best-studied agent of this class of compounds is triapine (3-amino-2-carboxaldehyde thiosemicarbazone), which has been tested in several phase I and II clinical trials. We synthesized triap...

متن کامل

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc-induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorigenesis. The accumulation of unfolded proteins in the ER initiates a cellular stress program termed the unfolded protein response (UPR) to support cel...

متن کامل

Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway

Herbal medicine as an alternative approach in the treatment of disease has drawn growing attention. Identification of the active ingredient is needed for effective utilization of the herbal medicine. Licorice is a popular herbal plant that is widely used to treat various diseases including liver diseases. Glycycoumarin (GCM) is a representative of courmarin compounds isolated from licorice. In ...

متن کامل

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Abeta), which triggers a cellular stress response called the unfolded protein response (UPR). The UPR signaling pathway is a cellular defense system for dealing with the accumulation of misfolded proteins but switches to apoptosis when endoplasmic reticulum (ER) stress is prolonged. ER stress is involved in ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Immune Network

سال: 2012

ISSN: 1598-2629,2092-6685

DOI: 10.4110/in.2012.12.6.253